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New Phase 3 Trial Explores Adding Immunotherapy to Chemotherapy for Metastatic Anal Cancer
A national Phase 3 trial (EA2176) is testing whether adding the immunotherapy drug nivolumab to standard chemotherapy improves outcomes for patients with metastatic anal cancer.
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New Clinical Trial Explores Combination Peptide-Based Strategy for HIV Remission
A new study is testing whether a combination therapy regimen, given alongside standard antiretroviral treatment, can help the immune system control HIV without continuous medication. Twenty participants will help researchers learn if durable remission is achievable.
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New Clinical Trial to Explore How Exercise Can Protect Muscle and Bone During GLP-1 Weight Loss
A newly registered study, GRAMS, will examine how GLP-1 receptor-based weight loss therapies affect muscle and bone health, and whether structured exercise can help preserve musculoskeletal strength during treatment.
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New Clinical Trial Explores Vorinostat for Difficult-to-Treat Crohn’s Disease
A new NIH-sponsored study is investigating whether the peptide-related compound vorinostat, followed by maintenance therapy with ustekinumab, could offer a fresh option for adults with moderate-to-severe Crohn’s disease that hasn’t responded to standard treatments.
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New Clinical Trial Explores Expanding Bone Marrow Transplant Options for Chronic Granulomatous Disease Patients
A new trial is investigating whether partially-matched family donors can safely provide curative bone marrow transplants for people with Chronic Granulomatous Disease who lack a perfect match.
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New Clinical Trial Compares Two Approaches to Spinal Fusion Bone Grafting
A newly registered clinical trial is examining how a bone graft substitute called ViviGen compares to recombinant human bone morphogenetic protein-2 (rhBMP-2) in helping patients achieve successful spinal fusion.
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New Clinical Trial Explores NAC to Protect Lungs During Cancer Radiation Therapy
A phase II trial is investigating whether N-acetylcysteine, alone or with short-course corticosteroids, can help reduce respiratory symptoms in lung cancer patients with interstitial lung disease undergoing radiation therapy.
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New Clinical Trial Explores Amino Acid Supplements to Help Dialysis Patients Feel Stronger
A new study is testing whether oral amino acid supplements taken during hemodialysis can reduce fatigue and frailty in patients with end-stage kidney disease.
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New Clinical Trial Explores Novel CCH Protocol for Peyronie’s Disease Non-Responders
A new study is investigating whether a modified collagenase clostridium histolyticum (CCH) treatment protocol can help men with Peyronie’s disease who didn’t respond to earlier CCH therapy.
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New Trial Explores Adding Immunotherapy to Boost Breast Cancer Treatment Response
A newly launched clinical trial is testing whether combining the immunotherapy QL1706 with standard endocrine therapy can help breast cancer patients who didn’t respond well to initial chemotherapy. The study offers a potential new option for a challenging-to-treat patient group.